Dataset Information

Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging.

ABSTRACT:

Background and purpose

The differential diagnosis of Parkinson syndromes remains a major challenge. Quantitative MR imaging can aid in this classification, but it is unclear which of the proposed techniques is best suited for this task. We, therefore, conducted a head-to-head study with different quantitative MR imaging measurements in patients with IPS, MSA-type Parkinson, PSP, and healthy elderly controls.

Materials and methods

Thirty-one patients and 13 controls underwent a comprehensive quantitative MR imaging protocol including R2*-, R2- and R1-mapping, magnetization transfer, and DTI with manual region-of-interest measurements in basal ganglia regions. Group differences were assessed with a post hoc ANOVA with a Bonferroni error correction and an ROC.

Results

The best separation of MSA from IPS in patients and controls could be achieved with R2*-mapping in the PU, with an ROC AUC of ≤0.96, resulting in a sensitivity of 77.8% (with a specificity 100%). MD was increased in patients with PSP compared with controls and to a lesser extent compared with those with IPS and MSA in the SN.

Conclusions

Among the applied quantitative MR imaging methods, R2*-mapping seems to have the best predictive power to separate patients with MSA from those with IPS, and DTI for identifying PSP.

SUBMITTER: Focke NK

PROVIDER: S-EPMC7964420 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Publications

Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging.

Focke N K NK Helms G G Pantel P M PM Scheewe S S Knauth M M Bachmann C G CG Ebentheuer J J Dechent P P Paulus W W Trenkwalder C C

AJNR. American journal of neuroradiology 20111013 11

<h4>Background and purpose</h4>The differential diagnosis of Parkinson syndromes remains a major challenge. Quantitative MR imaging can aid in this classification, but it is unclear which of the proposed techniques is best suited for this task. We, therefore, conducted a head-to-head study with different quantitative MR imaging measurements in patients with IPS, MSA-type Parkinson, PSP, and healthy elderly controls.<h4>Materials and methods</h4>Thirty-one patients and 13 controls underwent a com ...[more]

PMID: 21998102

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Dataset Information

Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging.

Background and purpose

Materials and methods

Results

Conclusions

Publications

Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging.

Similar Datasets

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