Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis.

ABSTRACT:

Background

The role of IL-12/23 in the pathogenesis of ulcerative colitis (UC) is unclear. We analyzed mucosal IL-12/23 expression and its relationship with endoscopic severity, histological activity, and UC relapse.

Methods

Rectal biopsies were collected from 70 UC patients with clinical remission. IL-12, IL-23, IFN-γ, IL-17A, and IL-17F mRNA expression was measured by real-time PCR. Endoscopic severity and histological activity were evaluated using the Mayo endoscopic subscore (MES) and the Geboes score, respectively.

Results

The longest follow-up period was 51 months. Thirty-four patients relapsed during the study period. Samples from these subsequently relapsed patients formed the "relapse" group, while those from patients that did not relapse formed the "remissio

SUBMITTER: Uchiyama K 

PROVIDER: S-EPMC7968323 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature