The association of human leukocyte antigen alleles with clinical disease progression in HIV-positive cohorts with varied treatment strategies.

ABSTRACT:

Objectives

The Strategic Timing of AntiRetroviral Treatment (START) and Strategies for Management of Antiretroviral Therapy (SMART) trials demonstrated that ART can partly reverse clinically defined immune dysfunction induced by HIV replication. As control of HIV replication is influenced by the HLA region, we explored whether HLA alleles independently influence the risk of clinical events in HIV+ individuals.

Design

Cohort study.

Methods

In START and SMART participants, associations between imputed HLA alleles and AIDS, infection-related cancer, herpes virus-related AIDS events, chronic inflammation-related conditions, and bacterial pneumonia were assessed. Cox regression was used to estimate hazard ratios for the risk of events among allele carriers versus noncarrie

SUBMITTER: Ekenberg C 

PROVIDER: S-EPMC7969421 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature