Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction.

ABSTRACT: Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcomes. Although control mechanisms associated with the receptors and their ligands are well understood, little is known with respect to the impact of lipid/lipid and lipid/protein interactions in the proximal plasma membrane environment. Given that the transmembrane regions of RTKs change in response to extracellular ligand binding, the lipid interactions have important consequences in influencing signal transduction. Fibroblast growth factor receptor 2 (FGFR2) is a highly regulated RTK, including under basal conditions. Binding of the adaptor protein, grow

SUBMITTER: Rohwedder A 

PROVIDER: S-EPMC7969938 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature