Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.

ABSTRACT: The purpose of this study was to investigate the effects of SLC22A2 808G>T polymorphism and trough concentrations (C₀) of bosutinib on serum creatinine in 28 patients taking bosutinib. At 1, 3, 6, 12, 24, and 36 months after administration, analysis of bosutinib C₀ and creatinine was performed at the same time of day. Significant correlations were observed between bosutinib C₀ and the change rate of serum creatinine or the estimated glomerular filtration rate (eGFR; r = 0.328, P < 0.001 and r = - 0.315, P < 0.001, respectively). These correlations were particularly high in patients having the SLC22A2 808G/G genotype (r = 0.345 and r = - 0.329, respectively); however, in patients having the 808T allele, there were no significant differences. In multivariate

SUBMITTER: Abumiya M 

PROVIDER: S-EPMC7973796 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature