Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis.

ABSTRACT:

Background

High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer survival. Tregs, a subset of CD4⁺ T lymphocytes, are mediators of immunosuppression in cancer, and therefore variants in genes related to Treg differentiation and function could be associated with colorectal cancer prognosis.

Methods

In a prospective German cohort of 3,593 colorectal cancer patients, we assessed the association of 771 single-nucleotide polymorphisms (SNP) in 58 Treg-related genes with overall and colorectal cancer-specific survival using Cox regression models. Effect modification by microsatellite instability (MSI) status was also investigated because tumors with MSI show greater lymphocytic infiltration a

SUBMITTER: Neumeyer S 

PROVIDER: S-EPMC7976673 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature