Evaluation of circulating tumor cell clusters for pan-cancer noninvasive diagnostic triaging.

ABSTRACT:

Background

Histopathologic examination (HPE) of tumor tissue obtained by invasive biopsy is the standard for cancer diagnosis but is resource-intensive and has been associated with procedural risks. The authors demonstrate that immunocytochemistry (ICC) profiling of circulating ensembles of tumor-associated cells (C-ETACs) can noninvasively provide diagnostic guidance in solid organ cancers.

Methods

The clinical performance of this approach was tested on blood samples from 30,060 individuals, including 9416 individuals with known cancer; 6725 symptomatic individuals with suspected cancer; and 13,919 asymptomatic individuals with no prior diagnosis of cancer. C-ETACs were harvested from peripheral blood and profiled by ICC for organ-specific and subtype-specific markers relev

SUBMITTER: Gaya A 

PROVIDER: S-EPMC7984349 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature