Dataset Information

The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data.

ABSTRACT: While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13-1.51]; obese = 1.37 [1.14-1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98-1.24]; obese = 1.20 [1.04-1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76-0.96]; obese = 0.82 [0.72-0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83-1.01]; obese = 0.87 [0.77-0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival.

SUBMITTER: Modi ND

PROVIDER: S-EPMC7985140 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data.

Modi Natansh D ND Tan Jin Quan Eugene JQE Rowland Andrew A Koczwara Bogda B Abuhelwa Ahmad Y AY Kichenadasse Ganessan G McKinnon Ross A RA Wiese Michael D MD Sorich Michael J MJ Hopkins Ashley M AM

NPJ breast cancer 20210322 1

While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13-1.51]; obese = 1.37 [1.14-1.64], P = < 0.001), and worse disease-free survi ...[more]

PMID: 33753745

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Dataset Information

The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data.

Publications

The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data.

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