Pinging the brain with transcranial magnetic stimulation reveals cortical reactivity in time and space.

ABSTRACT:

Background

Single-pulse transcranial magnetic stimulation (TMS) elicits an evoked electroencephalography (EEG) potential (TMS-evoked potential, TEP), which is interpreted as direct evidence of cortical reactivity to TMS. Thus, combining TMS with EEG can be used to investigate the mechanism underlying brain network engagement in TMS treatment paradigms. However, controversy remains regarding whether TEP is a genuine marker of TMS-induced cortical reactivity or if it is confounded by responses to peripheral somatosensory and auditory inputs. Resolving this controversy is of great significance for the field and will validate TMS as a tool to probe networks of interest in cognitive and clinical neuroscience.

Objective

Here, we delineated the cortical origin of TEP by spatially a

SUBMITTER: Ahn S 

PROVIDER: S-EPMC7987756 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature