Plasma Vitamin B12 Levels, High-Dose Vitamin B12 Treatment, and Risk of Dementia.

ABSTRACT:

Background

It is controversial whether B12 deficiency causes dementia or B12 treatment can prevent dementia.

Objective

To assess associations between low plasma (P-)B12 levels, B12 treatment, and risk of Alzheimer's disease (AD; primary outcome) and all-cause or vascular dementia (secondary outcomes).

Methods

We conducted a population-based cohort study using Danish registry data to assess associations between low P-B12 levels, high-dose injection or oral B12 treatment, and risk of dementia (study period 2000-2013). The primary P-B12 cohort included patients with a first-time P-B12 measurement whose subsequent B12 treatment was recorded. The secondary B12 treatment cohort included patients with a first-time B12 prescription and P-B12 measurement within one year before

SUBMITTER: Arendt JFH 

PROVIDER: S-EPMC7990402 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature