Na⁺ controls hypoxic signalling by the mitochondrial respiratory chain.

ABSTRACT: All metazoans depend on the consumption of O₂ by the mitochondrial oxidative phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O₂ to produce reactive oxygen species that can drive cell adaptations^1-4, a phenomenon that occurs in hypoxia^4-8 and whose precise mechanism remains unknown. Ca²⁺ is the best known ion that acts as a second messenger⁹, yet the role ascribed to Na⁺ is to serve as a mere mediator of membrane potential¹⁰. Here we show that Na⁺ acts as a second messenger that regulates OXPHOS function and the production of reactive oxygen species by modulating the fluidity of the inner mitochondrial membrane. A conformational shift in mitochondrial complex I

SUBMITTER: Hernansanz-Agustin P 

PROVIDER: S-EPMC7992277 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature