Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn2+ in protein glycosylation needed for host cell invasion and intracellular replication.
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ABSTRACT:
SUBMITTER: Ramakrishnan S
PROVIDER: S-EPMC7993795 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Deletion of a Golgi protein in Trypanosoma cruzi reveals a critical role for Mn2+ in protein glycosylation needed for host cell invasion and intracellular replication.
Ramakrishnan Srinivasan S Unger Linn M LM Baptista Rodrigo P RP Cruz-Bustos Teresa T Docampo Roberto R
PLoS pathogens 20210315 3
Trypanosoma cruzi is a protist parasite and the causative agent of American trypanosomiasis or Chagas disease. The parasite life cycle in its mammalian host includes an intracellular stage, and glycosylated proteins play a key role in host-parasite interaction facilitating adhesion, invasion and immune evasion. Here, we report that a Golgi-localized Mn2+-Ca2+/H+ exchanger of T. cruzi (TcGDT1) is required for efficient protein glycosylation, host cell invasion, and intracellular replication. The ...[more]
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