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Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study.


ABSTRACT: Surface-enhanced Raman scattering (SERS) is a powerful and sensitive technique for the detection of fingerprint signals of molecules and for the investigation of a series of surface chemical reactions. Many studies introduced quantitative applications of SERS in various fields, and several SERS methods have been implemented for each specific application, ranging in performance characteristics, analytes used, instruments, and analytical matrices. In general, very few methods have been validated according to international guidelines. As a consequence, the application of SERS in highly regulated environments is still considered risky, and the perception of a poorly reproducible and insufficiently robust analytical technique has persistently retarded its routine implementation. Collaborative trials are a type of interlaboratory study (ILS) frequently performed to ascertain the quality of a single analytical method. The idea of an ILS of quantification with SERS arose within the framework of Working Group 1 (WG1) of the EU COST Action BM1401 Raman4Clinics in an effort to overcome the problematic perception of quantitative SERS methods. Here, we report the first interlaboratory SERS study ever conducted, involving 15 laboratories and 44 researchers. In this study, we tried to define a methodology to assess the reproducibility and trueness of a quantitative SERS method and to compare different methods. In our opinion, this is a first important step toward a "standardization" process of SERS protocols, not proposed by a single laboratory but by a larger community.

SUBMITTER: Fornasaro S 

PROVIDER: S-EPMC7997108 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study.

Fornasaro Stefano S   Alsamad Fatima F   Baia Monica M   Batista de Carvalho Luís A E LAE   Beleites Claudia C   Byrne Hugh J HJ   Chiadò Alessandro A   Chis Mihaela M   Chisanga Malama M   Daniel Amuthachelvi A   Dybas Jakub J   Eppe Gauthier G   Falgayrac Guillaume G   Faulds Karen K   Gebavi Hrvoje H   Giorgis Fabrizio F   Goodacre Royston R   Graham Duncan D   La Manna Pietro P   Laing Stacey S   Litti Lucio L   Lyng Fiona M FM   Malek Kamilla K   Malherbe Cedric C   Marques Maria P M MPM   Meneghetti Moreno M   Mitri Elisa E   Mohaček-Grošev Vlasta V   Morasso Carlo C   Muhamadali Howbeer H   Musto Pellegrino P   Novara Chiara C   Pannico Marianna M   Penel Guillaume G   Piot Olivier O   Rindzevicius Tomas T   Rusu Elena A EA   Schmidt Michael S MS   Sergo Valter V   Sockalingum Ganesh D GD   Untereiner Valérie V   Vanna Renzo R   Wiercigroch Ewelina E   Bonifacio Alois A  

Analytical chemistry 20200221 5


Surface-enhanced Raman scattering (SERS) is a powerful and sensitive technique for the detection of fingerprint signals of molecules and for the investigation of a series of surface chemical reactions. Many studies introduced quantitative applications of SERS in various fields, and several SERS methods have been implemented for each specific application, ranging in performance characteristics, analytes used, instruments, and analytical matrices. In general, very few methods have been validated a  ...[more]

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