Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886).

ABSTRACT: Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

SUBMITTER: Yeh YT 

PROVIDER: S-EPMC7997245 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature