Two Faces of Vitamin C in Hemodialysis Patients: Relation to Oxidative Stress and Inflammation.

ABSTRACT: Hemodialysis (HD) is the most common method of renal replacement therapy. Besides toxins, it eliminates nutrients from the circulation, such as ascorbic acid (AA). HD-patients present AA deficiency more often than representatives of the general population, also due to dietary restrictions. This condition aggravates oxidative stress and inflammation related to uremia and extracorporeal circulation and increases cardiovascular risk followed by mortality. Supplementation of AA seems to be a promising approach in the treatment of hemodialysis patients. Many successful interventions restored plasma AA concentration in HD patients by enteral or intravenous supplementation, concomitantly inhibiting oxidative stress and inflammation. A significant number of studies reported opposite, serious pro-o

SUBMITTER: Chaghouri P 

PROVIDER: S-EPMC7997461 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature