Light-Triggered Catalytic Asymmetric Allylic Benzylation with Photogenerated C-Nucleophiles.

ABSTRACT: Herein is reported the asymmetric allylic benzylation of Morita-Baylis-Hillman (MBH) carbonates with 2-methylbenzophenone (MBP) derivatives as nonstabilized photogenerated C-nucleophiles. The dual activation of both reaction partners, chiral Lewis-base activation of the electrophile and light activation of the nucleophile, enables the stereoselective installation of benzyl groups at the allylic position to forge tertiary and quaternary carbon centers.

SUBMITTER: Paria S 

PROVIDER: S-EPMC7997570 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature