Integrative Biology of Diabetic Retinal Disease: Lessons from Diabetic Kidney Disease.

ABSTRACT: Diabetic retinal disease (DRD) remains the most common cause of vision loss in adults of working age. Progress on the development of new therapies for DRD has been limited by the complexity of the human eye, which constrains the utility of traditional research techniques, including animal and tissue culture models-a problem shared by those in the field of kidney disease research. By contrast, significant progress in the study of diabetic kidney disease (DKD) has resulted from the successful employment of systems biology approaches. Systems biology is widely used to comprehensively understand complex human diseases through the unbiased integration of genetic, environmental, and phenotypic aspects of the disease with the functional and structural manifestations of the disease. The applicatio

SUBMITTER: Pan WW 

PROVIDER: S-EPMC8003049 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature