BMI trajectory and subsequent risk of type 2 diabetes among middle-aged women.

ABSTRACT:

Background and aims

Little is known about how weight trajectories among women during menopausal transition and beyond may be related to risk of type 2 diabetes mellitus (T2DM). The aim of this study was to examine associations between body mass index (BMI) trajectories over 20 years, age of obesity onset, cumulative obese-years and incidence of T2DM among middle-aged women.

Methods and results

12,302 women enrolled in the Australian Longitudinal Study on Women's Health (ALSWH) were surveyed in 1996 (Survey 1, age 45-50), 1998 and then every three years to 2016. Self-reported weight and height were collected for up to eight time points. Incident diabetes was assessed via validated self-report of physician-diagnosed diabetes. Growth mixture models were used to identify distinc

SUBMITTER: Luo J 

PROVIDER: S-EPMC8005471 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature