Dataset Information

Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort.

ABSTRACT:

Background

The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.

Methods

The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control.

Results

During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV₁ and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged.

Conclusion

Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.

SUBMITTER: Papadopoulos NG

PROVIDER: S-EPMC8013557 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort.

Papadopoulos Nikolaos G NG Mathioudakis Alexander G AG Custovic Adnan A Deschildre Antoine A Phipatanakul Wanda W Wong Gary G Xepapadaki Paraskevi P Abou-Taam Rola R Agache Ioana I Castro-Rodriguez Jose A JA Chen Zhimin Z Cros Pierrick P Dubus Jean-Christophe JC El-Sayed Zeinab Awad ZA El-Owaidy Rasha R Feleszko Wojciech W Fierro Vincenzo V Fiocchi Alessandro A Garcia-Marcos Luis L Goh Anne A Hossny Elham M EM Huerta Villalobos Yunuen R YR Jartti Tuomas T Le Roux Pascal P Levina Julia J López García Aida Inés AI Ramos Ángel Mazón ÁM Morais-Almeida Mário M Murray Clare C Nagaraju Karthik K Nagaraju Major K MK Navarrete Rodriguez Elsy Maureen EM Namazova-Baranova Leyla L Nieto Garcia Antonio A Pozo Beltrán Cesar Fireth CF Ratchataswan Thanaporn T Rivero Yeverino Daniela D Rodríguez Zagal Eréndira E Schweitzer Cyril E CE Tulkki Marleena M Wasilczuk Katarzyna K Xu Dan D

Allergy 20210324 6

<h4>Background</h4>The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.<h4>Methods</h4>The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic betwe ...[more]

PMID: 33608919

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Dataset Information

Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort.

Background

Methods

Results

Conclusion

Publications

Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort.

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