Ontology highlight
ABSTRACT:
SUBMITTER: Karges J
PROVIDER: S-EPMC8014511 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Karges Johannes J Kalaj Mark M Gembicky Milan M Cohen Seth M SM
Angewandte Chemie (International ed. in English) 20210326 19
Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CL<sup>pro</sup> ), which is also known as the main protease, is considered among the most important pharmacological targets. The vast majority of investigated 3CL<sup>p ...[more]