A new synthetic protectin D1 analog 3-oxa-PD1_{n-3 DPA} reduces neuropathic pain and chronic itch in mice.

ABSTRACT: The resolution of inflammation is a biosynthetically active process controlled by the interplay between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling pathways. These enzymatically oxygenated polyunsaturated fatty acids belong to distinct families of specialized pro-resolving autacoids. The protectin family of mediators has attracted an interest because of their potent pro-resolving and anti-inflammatory actions verified in several in vivo disease models. Herein, we present the stereoselective synthesis and biological evaluations of 3-oxa-PD1_{n-3 DPA}, a protectin D1 analog. Results from mouse models indicate that the mediators protectin D1, PD1_{n-3 DPA} and the new analog 3-oxa-PD1_{n-3 DPA} all relieved streptozotocin-induced diabe

SUBMITTER: Nesman JI 

PROVIDER: S-EPMC8016805 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature