Differential gene expression analysis of palbociclib-resistant TNBC via RNA-seq.

ABSTRACT:

Purpose

The management of triple-negative breast cancer (TNBC) remains a significant clinical challenge due to the lack of effective targeted therapies. Inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6) are emerging as promising therapeutic agents against TNBC; however, cells can rapidly acquire resistance through multiple mechanisms that are yet to be identified. Therefore, determining the mechanisms underlying resistance to CDK4/6 inhibition is crucial to develop combination therapies that can extend the efficacy of the CDK4/6 inhibitors or delay resistance. This study aims to identify differentially expressed genes (DEG) associated with acquired resistance to palbociclib in ER- breast cancer cells.

Methods

We performed next-generation transcriptomic sequencing (

SUBMITTER: Lanceta L 

PROVIDER: S-EPMC8019424 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature