Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in Apc ^Min/+ Mice: Relation to Metabolism and Gut Microbiota Composition.

ABSTRACT: Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and gut microbiota profiling in a colorectal cancer mouse model (Apc ^Min/+ ). Ffar2 deficiency promoted colonic polyp development and enhanced fatty acid oxidation and bile acid metabolism. Gut microbiome sequencing analysis showed distinct clustering among wild-type, Apc ^Min/+ , and Apc ^Min/+ -Ffar2 ^-/- mice. The relative abundance of Flavobacteriaceae and Verrucomicrobiaceae was significantly increased in the Apc ^Min/+ -Ffar2 ^-/- mice c

SUBMITTER: Huang YW 

PROVIDER: S-EPMC8020170 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature