A Thioether-Ligated Cupric Superoxide Model with Hydrogen Atom Abstraction Reactivity.

ABSTRACT: The central role of cupric superoxide intermediates proposed in hormone and neurotransmitter biosynthesis by noncoupled binuclear copper monooxygenases like dopamine-β-monooxygenase has drawn significant attention to the unusual methionine ligation of the Cu_M ("Cu_B") active site characteristic of this class of enzymes. The copper-sulfur interaction has proven critical for turnover, raising still-unresolved questions concerning Nature's selection of an oxidizable Met residue to facilitate C-H oxygenation. We describe herein a model for Cu_M, [(^TMGN₃S)Cu^I]⁺ ([1]⁺), and its O₂-bound analog [(^TMGN₃S)Cu^II(O₂^•-)]⁺ ([1·O<

SUBMITTER: Bhadra M 

PROVIDER: S-EPMC8023764 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature