Association of molecular subtype concordance and survival outcome in synchronous and metachronous bilateral breast cancer.

ABSTRACT:

Background

The aim of this study was to analyze the association of molecular subtype concordance and disease outcome in patients with synchronous bilateral breast cancer (SBBC) and metachronous breast cancer (MBBC).

Patients and methods

Patients diagnosed with SBBC or MBBC in the Surveillance, Epidemiology, and End Results (SEER) database or Comprehensive Breast Health Center (CBHC) Ruijin Hospital, Shanghai were retrospectively reviewed and included. Clinicopathologic features, molecular subtype status concordance, and prognosis were compared in patients with SBBC and MBBC. Other prognostic factors for breast cancer-specific survival (BCSS) and overall survival (OS) were also identified for bilateral breast cancer patients.

Results

Totally, 3395 and 115 patients were

SUBMITTER: Ding S 

PROVIDER: S-EPMC8027898 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature