Homologous recombination repair gene mutations show no survival benefits in Chinese high-grade serous ovarian cancer patients.

ABSTRACT:

Background

The purpose of our study was to identify germline and somatic homologous recombination repair (HRR) pathway gene mutations and their clinical-prognostic impact in Chinese high-grade serous ovarian cancer (HGSC) patients.

Methods

We applied next-generation sequencing (NGS) in consecutive patients who underwent primary surgery for HGSC in November and December 2015 at our institution. Paired peripheral blood (or para-carcinoma tissue) samples and tumor samples from 42 Chinese women were tested to identify both germline and somatic deleterious mutations through all exons in BRCA1/2 and 22 other core HRR genes. Clinic-pathological data were collected until February, 2020. Associations between HRR gene mutations and clinical characters and outcomes were also eva

SUBMITTER: Feng Z 

PROVIDER: S-EPMC8033363 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature