Integrated study of miR-215 promoting breast cancer cell apoptosis by targeting RAD54B.

ABSTRACT:

Background

MicroRNAs (miRNAs) are widely distributed in cells and participate in the regulation of the pathophysiological process of many diseases. As an important part of non-coding RNA, miRNAs regulate a variety of molecules and signal pathways in tumour cells. However, the evidence for regulatory mechanisms of specific miRNAs in tumour cells is still lacking.

Methods

In this study, we used transcriptomics analysis and integrated a variety of public databases to screen miRNAs that have key regulatory effects on breast cancer (BC). In addition, we used in vitro and in vivo studies and combined clinical samples to verify its regulatory mechanism.

Results

We found that among the specific miRNAs, miR-215-5p is a key regulator in BC. Compared with normal adjacent tissues

SUBMITTER: Wang M 

PROVIDER: S-EPMC8034472 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature