Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.

ABSTRACT: Caloric restriction (CR) can prolong aged skeletal muscle function, yet the molecular mechanisms are not completely understood. We performed phosphoproteomic analysis on muscle from young and old mice fed an ad libitum diet, and old mice fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing several known "pro-aging" pathways including Protein kinase A (PKA). This study validates global signaling changes in skeletal muscle during CR.

SUBMITTER: Bareja A 

PROVIDER: S-EPMC8035222 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature