A first step towards a global nomogram to predict disease progression for men on active surveillance.

ABSTRACT:

Background

Signs of disease progression (28%) and conversion to active treatment without evidence of disease progression (13%) are the main reasons for discontinuation of active surveillance (AS) in men with localised prostate cancer (PCa). We aimed to develop a nomogram to predict disease progression in these patients.

Methods

As a first step in the development of a nomogram, using data from Movembers' GAP3 Consortium (n=14,380), we assessed heterogeneity between centres in terms of risk of disease progression. We started with assessment of baseline hazards for disease progression based on grouping of centres according to follow-up protocols [high: yearly; intermediate: ~2 yearly; and low: at year 1, 4 & 7 (i.e., PRIAS)]. We conducted cause-specific random effect Cox propor

SUBMITTER: Van Hemelrijck M 

PROVIDER: S-EPMC8039580 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature