1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry.
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ABSTRACT:
SUBMITTER: Aprile S
PROVIDER: S-EPMC8040252 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry.
Aprile Silvio S Riva Beatrice B Bhela Irene Preet IP Cordero-Sanchez Celia C Avino Giulia G Genazzani Armando A AA Serafini Marta M Pirali Tracey T
ACS medicinal chemistry letters 20210310 4
Store-operated calcium entry (SOCE) is a pivotal mechanism in calcium homeostasis, and, despite still being under investigation, its dysregulation is known to be associated with severe human disorders. SOCE modulators are therefore needed both as chemical probes and as therapeutic agents. While many small molecules have been described so far, their poor properties in terms of drug-likeness have limited their translation into the clinical practice. In this work, we describe the bioisosteric repla ...[more]
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