BMSC seeding in different scaffold incorporation with hyperbaric oxygen treats seawater-immersed bony defect.

ABSTRACT:

Introduction

The experiment was undertaken to estimate the effect of BMSC seeding in different scaffold incorporation with HBO on the repair of a seawater-immersed bone defect. And future compared n-HA/PLGA with β-TCP/PLGA as a scaffold in treatment effect of the seawater-immersed bone defect.

Methods

Sixty New Zealand White rabbits with standard seawater defect in radius were randomly divided into group A (implant with nothing), group B (implanted with autogenous bone), group C (implanted with n-HA/PLGA/BMSCs), and group D (implanted with β-TCP/PLGA/BMSCs). After the implant, each rabbit receives HBO treatment at 2.4 ATA 100% oxygen for 120 min/day for 2 weeks. Radiograph, histological, and biomechanical examinations were used to analyze osteogenesis.

Result

X-ray an

SUBMITTER: Zhang G 

PROVIDER: S-EPMC8042966 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature