Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.

ABSTRACT:

Introduction

Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians.

Methods

Incidence of NPS was examined in participants with normal cognition who progressed to all-cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence across 7.6 ± 3.0 years of follow-up.

Results

Participants with TBI history had increased prevalence and incidence of apathy (44.7% vs 29.9%, P = .0062; HR_adj. = 1.708, P = .0018) and motor disturbances (17.2% vs 9.5%, P = .0458; HR_adj. = 2.023, P = .0168), controlling for

SUBMITTER: Bray MJC 

PROVIDER: S-EPMC8043985 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature