Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.
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ABSTRACT: Introduction
Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians.Methods
Incidence of NPS was examined in participants with normal cognition who progressed to all-cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence across 7.6 ± 3.0 years of follow-up.Results
Participants with TBI history had increased prevalence and incidence of apathy (44.7% vs 29.9%, P = .0062; HRadj. = 1.708, P = .0018) and motor disturbances (17.2% vs 9.5%, P = .0458; HRadj. = 2.023, P = .0168), controlling for demographics and type of dementia diagnosis. Earlier anxiety onset was associated with TBI (692 days prior to dementia diagnosis vs 161 days, P = .0265).Discussion
History of TBI is associated with increased risk for and earlier onset of NPS in the trajectory of dementia development.
SUBMITTER: Bray MJC
PROVIDER: S-EPMC8043985 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.
Bray Michael J C MJC Richey Lisa N LN Bryant Barry R BR Krieg Akshay A Jahed Sahar S Tobolowsky William W LoBue Christian C Peters Matthew E ME
Alzheimer's & dementia : the journal of the Alzheimer's Association 20210119 4
<h4>Introduction</h4>Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians.<h4>Methods</h4>Incidence of NPS was examined in participants with normal cognition who progressed to all-cause dementia based on whether TBI history was present (n = 130) or absent (n = 849). Survival analyses were used to examine NPS incidence ac ...[more]
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