Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans.

ABSTRACT:

Objectives

To assess traumatic brain injury (TBI)-related risks factors for early-onset dementia (EOD).

Background

Younger Post-9/11 Veterans may be at elevated risk for EOD due to high rates of TBI in early/mid adulthood. Few studies have explored the longitudinal relationship between traumatic brain injury (TBI) and the emergence of EOD subtypes.

Methods

This matched case-control study used data from the Veterans Health Administration (VHA) to identify Veterans with EOD. To address the low positive predictive value (PPV = 0.27) of dementia algorithms in VHA records, primary outcomes were Alzheimer's disease (AD) and frontotemporal dementia (FTD). Logistic regression identified conditions associated with dementia subtypes.

Results

The EOD cohort included Veter

SUBMITTER: Kennedy E 

PROVIDER: S-EPMC9187585 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature