Enhanced reinstatement of naturalistic event memories due to hippocampal-network-targeted stimulation.

ABSTRACT: Episodic memory involves the reinstatement of distributed patterns of brain activity present when events were initially experienced. The hippocampus is thought to coordinate reinstatement via its interactions with a network of brain regions, but this hypothesis has not been causally tested in humans. The current study directly tested the involvement of the hippocampal network in reinstatement using network-targeted noninvasive stimulation. We measured reinstatement of multi-voxel patterns of functional magnetic resonance imaging (fMRI) activity during encoding and retrieval of naturalistic video clips depicting everyday activities. Reinstatement of video-specific activity patterns was robust in posterior parietal and occipital areas previously implicated in event reinstatement. Theta-burst

SUBMITTER: Hebscher M 

PROVIDER: S-EPMC8044012 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature