Panels and models for accurate prediction of tumor mutation burden in tumor samples.
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ABSTRACT:
SUBMITTER: Martinez-Perez E
PROVIDER: S-EPMC8044185 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Panels and models for accurate prediction of tumor mutation burden in tumor samples.
Martínez-Pérez Elizabeth E Molina-Vila Miguel Angel MA Marino-Buslje Cristina C
NPJ precision oncology 20210413 1
Immune checkpoint blockade (ICB) is becoming standard-of-care in many types of human malignancies, but patient selection is still imperfect. Tumor mutation burden (TMB) is being evaluated as a biomarker for ICB in clinical trials, but most of the sequencing panels used to estimate it are inadequately designed. Here, we present a bioinformatics-based method to select panels and mathematical models for accurate TMB prediction. Our method is based on tumor-specific, forward-step selection of genes, ...[more]
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