Ontology highlight
ABSTRACT:
SUBMITTER: Annapureddy RR
PROVIDER: S-EPMC8048691 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Annapureddy Rajasekar Reddy RR Burg Finn F Gramüller Johannes J Golub Tino P TP Merten Christian C Huber Stefan M SM Bach Thorsten T
Angewandte Chemie (International ed. in English) 20210226 14
An enantioselective sulfimidation of 3-thiosubstituted 2-quinolones and 2-pyridones was achieved with a stoichiometric nitrene source (PhI=NNs) and a silver-based catalyst system. Key to the success of the reaction is the use of a chiral phenanthroline ligand with a hydrogen bonding site. The enantioselectivity does not depend on the size of the two substituents at the sulfur atom but only on the binding properties of the heterocyclic lactams. A total of 21 chiral sulfimides were obtained in hig ...[more]