The Total Synthesis of Chondrochloren A.

ABSTRACT: The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.

SUBMITTER: Linne Y 

PROVIDER: S-EPMC8048958 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature