CCL20 in psoriasis: A potential biomarker of disease severity, inflammation, and impaired vascular health.

ABSTRACT:

Background

Psoriasis is associated with increased cardiovascular risk that is not captured by traditional proinflammatory biomarkers.

Objective

To investigate the relationship between Psoriasis Area and Severity Index, circulating proinflammatory biomarkers, and vascular health in psoriasis.

Methods

In patients with psoriasis and in age and sex-matched controls, 273 proteins were analyzed with the Proseek Multiplex Cardiovascular disease reagents kit and Inflammatory reagents kit (Olink Bioscience), whereas vascular endothelial inflammation and health were measured via direct transcriptomic analysis of brachial vein endothelial cells.

Results

In psoriasis, chemokine ligand 20 (CCL20), interleukin (IL) 6, and IL-17A were the top 3 circulating proinflammatory cyt

SUBMITTER: Elnabawi YA 

PROVIDER: S-EPMC8049184 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature