A novel allele of the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling.

ABSTRACT: Immune recognition in plants is governed by two major classes of receptors: pattern recognition receptors (PRRs) and nucleotide-binding leucine-rich repeat receptors (NLRs). Located at the cell surface, PRRs bind extracellular ligands originating from microbes (indicative of "non-self") or damaged plant cells (indicative of "infected-self"), and trigger signaling cascades to protect against infection. Located intracellularly, NLRs sense pathogen-induced physiological changes and trigger localized cell death and systemic resistance. Immune responses are under tight regulation in order to maintain homeostasis and promote plant health. In a forward-genetic screen to identify regulators of PRR-mediated immune signaling, we identified a novel allele of the membrane-attack complex and perforin (

SUBMITTER: Holmes DR 

PROVIDER: S-EPMC8049551 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature