Unveiling the Dynamics of KRAS4b on Lipid Model Membranes.

ABSTRACT: Small GTPase proteins are ubiquitous and responsible for regulating several processes related to cell growth and differentiation. Mutations that stabilize their active state can lead to uncontrolled cell proliferation and cancer. Although these proteins are well characterized at the cellular scale, the molecular mechanisms governing their functions are still poorly understood. In addition, there is limited information about the regulatory function of the cell membrane which supports their activity. Thus, we have studied the dynamics and conformations of the farnesylated KRAS4b in various membrane model systems, ranging from binary fluid mixtures to heterogeneous raft mimics. Our approach combines long time-scale coarse-grained (CG) simulations and Markov state models to dissect the membran

SUBMITTER: Lopez CA 

PROVIDER: S-EPMC8052243 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature