Advances in epigenetic therapeutics with focus on solid tumors.
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ABSTRACT:
SUBMITTER: Jin N
PROVIDER: S-EPMC8056722 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Advances in epigenetic therapeutics with focus on solid tumors.
Jin Ning N George Tiffany L TL Otterson Gregory A GA Verschraegen Claire C Wen Haitao H Carbone David D Herman James J Bertino Erin M EM He Kai K
Clinical epigenetics 20210420 1
Epigenetic ("above genetics") modifications can alter the gene expression without altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA methylation, histone methylation, histone acetylation, non-coding RNA, and mRNA methylation. Epigenetic-targeted agents have demonstrated clinical activities in hematological malignancies and therapeutic potential in solid tumors. In this review, we describe mechanisms of various epigenetic modifications, discuss the Food and Drug Admi ...[more]
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