Genome-Wide Analysis of Copy Number Variation in Latin American Parkinson's Disease Patients.

ABSTRACT:

Background

Parkinson's disease is the second most common neurodegenerative disorder and affects people from all ethnic backgrounds, yet little is known about the genetics of Parkinson's disease in non-European populations. In addition, the overall identification of copy number variants at a genome-wide level has been understudied in Parkinson's patients. The objective of this study was to understand the genome-wide burden of copy number variants in Latinos and its association with Parkinson's disease.

Methods

We used genome-wide genotyping data from 747 Parkinson's disease patients and 632 controls from the Latin American Research Consortium on the Genetics of Parkinson's disease.

Results

Genome-wide copy number burden analysis showed that patients were significantly

SUBMITTER: Sarihan EI 

PROVIDER: S-EPMC8059262 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature