Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors.

ABSTRACT: Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume (vv¯), a stereological estimation that provides information about nuclear size and its variability. vv¯ of 55 ccMCTs was estimated using the "point-sampled intercept" method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in vv¯ were found between grade II (x¯ = 115 ± 29 µm³) and grade III ccMCTs (x ¯= 197 ± 63 µm³), as well a

SUBMITTER: Casanova M 

PROVIDER: S-EPMC8064533 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature