Can 'floating' predict treatment response to ketamine? Data from three randomized trials of individuals with treatment-resistant depression.

ABSTRACT: Ketamine has rapid-acting antidepressant properties but also potentially concerning transient dissociative side effects (SEs). Recent studies noted a positive correlation between treatment response to ketamine and general dissociative SEs, as well as "floating", a depersonalization SE (a subtype of the dissociative SEs). This analysis sought to determine whether floating mediates treatment response to ketamine. Data were pooled from three double-blind, crossover, placebo-controlled ketamine clinical trials across which 82 participants with treatment-resistant depression (TRD) (44 with bipolar depression and 38 with major depressive disorder) received placebo and ketamine (0.5 mg/kg) infusions. SEs were actively solicited in a standardized fashion before and after ketamine infusion. The hyp

SUBMITTER: Acevedo-Diaz EE 

PROVIDER: S-EPMC8073211 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature