Altered SOCS3 DNA methylation within exon 2 is associated with increased mRNA expression in visceral adipose tissue in gestational diabetes.
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ABSTRACT:
SUBMITTER: Rancourt RC
PROVIDER: S-EPMC8078723 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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Altered <i>SOCS3</i> DNA methylation within exon 2 is associated with increased mRNA expression in visceral adipose tissue in gestational diabetes.
Rancourt Rebecca C RC Ott Raffael R Schellong Karen K Ziska Thomas T Melchior Kerstin K Henrich Wolfgang W Plagemann Andreas A
Epigenetics 20200812 5
Overweight/obesity is the main risk factor for gestational diabetes mellitus (GDM). In our cohort of pregnant women with GDM, n = 19, and without, n = 22, we previously reported a significant increase in <i>SOCS3</i> mRNA expression (+62%) in visceral adipose tissue (VAT) according to GDM, without altered promoter DNA-methylation. Here, we examined methylation status of additional <i>SOCS3</i> exon 2 regions in VAT and maternal blood. We found significantly altered methylation at specific CpG si ...[more]
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