Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies.

ABSTRACT: Glycosylation, the enzymatic attachment of carbohydrates to proteins and lipids, regulates nearly all cellular processes and is critical in the development and function of the nervous system. Axon pathfinding, neurite outgrowth, synaptogenesis, neurotransmission, and many other neuronal processes are regulated by glycans. Over the past 25 years, studies analyzing post-mortem brain samples have found evidence of aberrant glycosylation in individuals with schizophrenia. Proteins involved in both excitatory and inhibitory neurotransmission display altered glycans in the disease state, including AMPA and kainate receptor subunits, glutamate transporters EAAT1 and EAAT2, and the GABA_A receptor. Polysialylated NCAM (PSA-NCAM) and perineuronal nets, highly glycosylated molecules critic

SUBMITTER: Williams SE 

PROVIDER: S-EPMC8081047 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature