Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning.
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ABSTRACT:
SUBMITTER: Alexander L
PROVIDER: S-EPMC8082163 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning.
Alexander Laith L Banai-Tizkar Rana R Wood Christian M CM Roberts Angela C AC
STAR protocols 20210417 2
Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, <i>Callithrix jacchus</i>, on an appetitive Pavlovian conditioning paradigm to measure behavioral and cardiovascular correlates of anticipatory and consummatory phases of reward processing. We describe how to use intracerebral infusions to manipulate brain regions whose activity is relevant to impaired reward processing in depression an ...[more]
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