Insights into Glucose-6-phosphate Allosteric Activation of β-Glucosidase A.

ABSTRACT: Second-generation ethanol production involves the use of agricultural and forestry waste as feedstock, being an alternative to the first-generation technology as it relies on low-cost abundant residues and does not affect food agriculture. However, the success of second-generation biorefineries relies on energetically efficient processes and effective enzyme cocktails to convert cellulose into fermentable sugars. β-glucosidases catalyze the last step on the enzymatic hydrolysis of cellulose; however, they are often inhibited by glucose. Previous studies demonstrated that glucose-6-phosphate (G6P) is a positive allosteric modulator of Bacillus polymyxa β-glucosidase A, improving enzymatic efficiency, providing thermoresistance, and imparting glucose tolerance. However, the precise mo

SUBMITTER: A Gomes A 

PROVIDER: S-EPMC8085047 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature