Comparative analyses of the soft tissue interfaces around teeth and implants: Insights from a pre-clinical implant model.

ABSTRACT:

Aim

To evaluate the similarities and differences in barrier function of a peri-implant epithelium (PIE) versus a native junctional epithelium (JE).

Materials and methods

A mouse model was used wherein titanium implants were placed sub-occlusally in healed extraction sites. The PIE was examined at multiple timepoints after implant placement, to capture and understand the temporal nature of its assembly and homeostatic status. Mitotic activity, hemidesmosomal attachment apparatus, and inflammatory responses in the PIE were compared against a JE. Additionally, we evaluated whether the PIE developed a Wnt-responsive stem cell niche like a JE.

Results

The PIE developed from oral epithelium (OE) that had, by the time of implant placement, lost all characteristics of a JE. C

SUBMITTER: Yuan X 

PROVIDER: S-EPMC8085107 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature