Cultivable Bacteria in Urine of Women With Interstitial Cystitis: (Not) What We Expected.

ABSTRACT:

Objective

Multiple studies show cultivatable bacteria in urine of most women. The existence of these bacteria challenges interstitial cystitis (IC)/painful bladder syndrome (PBS) diagnosis, which presumes a sterile bladder. The aims of this study were (1) to compare the female bladder microbiomes in women with IC/PBS and unaffected controls and (2) to correlate baseline bladder microbiome composition with symptoms.

Methods

This cross-sectional study enrolled 49 IC/PBS and 40 controls. All provided catheterized urine samples and completed validated questionnaires. A subset of the IC/PBS cohort provided voided and catheterized urine samples. All samples from both cohorts were assessed by the expanded quantitative urine culture (EQUC) protocol; a subset was assessed by 16S rRNA

SUBMITTER: Jacobs KM 

PROVIDER: S-EPMC8088819 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature